Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421003 | 0.82 | POLB (0.59) | POLBALDH1A1MAPTGAAKDM4E | |
| SCHEMBL7317448 | 0.82 | GAA (0.59) | POLBALDH1A1MAPTGAAKDM4E | |
| SCHEMBL2702444 | 0.79 | ALDH1A1 (0.79) | ALDH1A1MAPTGAANPSR1HTT | |
| SCHEMBL3834699 | 0.79 | ALDH1A1 (0.57) | POLBALDH1A1GAAKDM4ETDP1 | |
| SCHEMBL7571584 | 0.78 | SLC40A1 (0.66) | POLBALDH1A1MAPTGAAKDM4E | |
| SCHEMBL13949767 | 0.76 | POLB (0.68) | POLBALDH1A1MAPTGAAKDM4E | |
| SCHEMBL7569885 | 0.76 | ALDH1A1 (0.59) | POLBALDH1A1MAPTGAANPSR1 | |
| SCHEMBL1011405 | 0.76 | KMT2A (0.63) | POLBALDH1A1MAPTTDP1HTT | |
| SCHEMBL10931486 | 0.75 | MAPT (0.51) | POLBALDH1A1MAPTGAATDP1 | |
| SCHEMBL11851628 | 0.75 | GAA (0.49) | ALDH1A1GAANPSR1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103720-A | ENZYME INHIBITORS; ANTIICHEMIC AND -TUMOR AGENTS; STROKES; ALZEIMER'S DISEASE | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-15 | — | — | US | disclosed |
| CN-1245486-A | Ketobenzamides as calpain inhibitors | BASF AG (DE) | 2000-02-23 | — | — | CN | disclosed |