Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.53 |
| ▸ | ITGAV | P06756 | 12/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382418 | 0.89 | ITGB3 (0.43) | ITGB3ITGA2BITGAVDRD2DRD3 | |
| SCHEMBL7653549 | 0.89 | ITGB3 (0.47) | ITGB3ITGA2BITGAVMMP3HTR1A | |
| SCHEMBL383368 | 0.86 | ITGB3 (0.73) | ITGB3ITGA2BITGAVMMP3ITGB1 | |
| SCHEMBL27475491 | 0.82 | ITGB3 (0.46) | ITGB3ITGA2BITGAVDRD2DRD3 | |
| SCHEMBL383511 | 0.82 | ITGB3 (0.46) | ITGB3ITGA2BITGAVDRD2DRD3 | |
| SCHEMBL382134 | 0.82 | ITGB3 (0.73) | ITGB3ITGA2BITGAV | |
| SCHEMBL7650144 | 0.81 | ITGB3 (0.55) | ITGB3ITGA2BITGAVMMP3ITGB1 | |
| SCHEMBL7651464 | 0.81 | HTR1A (0.41) | ITGB3ITGA2BITGAVDRD2DRD3 | |
| SCHEMBL382419 | 0.80 | DRD2 (0.40) | ITGB3ITGA2BITGAVDRD2DRD3 | |
| SCHEMBL382123 | 0.79 | ITGB3 (0.68) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | claimed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |