Homoserine

Homoserine

SCHEMBL383537

NC(CCO)C(=O)O.O=P(O)(O)O

nearest known ligand 0.59

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Homoserine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLUL P15104 1/20 0.53
GRM8 O00222 2/20 0.52
GRM6 O15303 2/20 0.52
GRM7 Q14831 2/20 0.52
GRM4 Q14833 2/20 0.52
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GSR P00390 1/20 0.50
CYP1A2 P05177 1/20 0.50
GRIK1 P39086 1/20 0.50
GRM5 P41594 1/20 0.50
GRIA1 P42261 1/20 0.50
GRIA2 P42262 1/20 0.50
GRIA3 P42263 1/20 0.50
SLC1A3 P43003 1/20 0.50
SLC1A2 P43004 1/20 0.50
SLC1A1 P43005 1/20 0.50
GRIA4 P48058 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Homoserine SCHEMBL60700 1.00 GLUL (0.53) GLULGRM8GRM6GRM7GRM4
Homoserine SCHEMBL27518745 1.00 GLUL (0.53) GLULGRM8GRM6GRM7GRM4
Homoserine SCHEMBL6447119 0.90 GSR (0.59) GRM8GRM6GRM7GRM4GRIN2D
Homoserine SCHEMBL29649 0.90
Homoserine SCHEMBL60060 0.90
Homoserine SCHEMBL4944178 0.90 GSR (0.59) GRM8GRM6GRM7GRM4GRIN2D
Homoserine SCHEMBL6446994 0.90 GSR (0.59) GRM8GRM6GRM7GRM4GRIN2D
Homoserine SCHEMBL29648 0.90
Homoserine SCHEMBL23748103 0.87
Homoserine SCHEMBL9471942 0.87 GSR (0.56) GRM8GRM6GRM7GRM4GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2851421-B1 USEFUL MICROORGANISM, AND METHOD FOR PRODUCING SUBSTANCE OF INTEREST KAO CORP (JP) 2018-11-28 EP claimed
US-20150197775-A1 USEFUL MICROORGANISM AND METHOD FOR PRODUCING SUBSTANCE OF INTEREST GENARIS, INC. (JP) 2015-07-16 US claimed
EP-2851421-A1 USEFUL MICROORGANISM, AND METHOD FOR PRODUCING DESIRED SUBSTANCE Genaris, Inc. (JP) 2015-03-25 EP claimed
CN-104379729-A Useful microorganism, and method for producing desired substance GENARIS INC 2015-02-25 CN claimed
EP-0338790-A2 Production of homoserine and its derivatives such as threonine derivatives and methionine precursors BIOTECHNICA INTERNATIONAL, INC. (US) 1989-10-25 EP claimed
CN-119979428-A Recombinant bacterium for synthesizing L-homoserine and L-threonine by using fatty acid and application thereof 微元合成生物技术(北京)有限公司 2025-05-13 CN disclosed
CN-111944781-A Mutant homoserine kinase and application thereof 廊坊梅花生物技术开发有限公司 2020-11-17 CN disclosed
US-10781461-B2 Useful microorganism and method for producing substance of interest KAO CORPORATION (JP) 2020-09-22 US disclosed
US-20200294617-A1 A GRAPH-BASED CONSTANT-COLUMN BICLUSTERING DEVICE AND METHOD FOR MINING GROWTH PHENOTYPE DATA KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2020-09-17 US disclosed
EP-3701532-A1 A GRAPH-BASED CONSTANT-COLUMN BICLUSTERING DEVICE AND METHOD FOR MINING GROWTH PHENOTYPE DATA King Abdullah University Of Science And Technology (SA) 2020-09-02 EP disclosed
CN-104379729-B Process for producing useful microorganism and target substance 花王株式会社 2020-07-21 CN disclosed
CN-110267655-A The treatment method of amino acid composition and muscle disease and illness 胺细拉健康公司 2019-09-20 CN disclosed
CN-1226931-A Escherichia coli strains and preparation thereof and use thereof in fermentation process for production of L-threonine ARCHER DANIELS MIDLAND CO (US) 1999-08-25 CN disclosed
US-5939307-A GENETIC ENGINEERING THE ARCHER-DANIELS-MIDLAND COMPANY (US) 1999-08-17 US disclosed
EP-0917578-A1 NOVEL STRAINS OF $i(ESCHERICHIA COLI), METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION ARCHER-DANIELS-MIDLAND COMPANY (US) 1999-05-26 EP disclosed
WO-1998004715-A9 NOVEL STRAINS OF ESCHERICHIA COLI, METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION 1998-05-22 WO disclosed
WO-1998004715-A1 NOVEL STRAINS OF ESCHERICHIA COLI, METHODS OF PREPARING THE SAME AND USE THEREOF IN FERMENTATION PROCESSES FOR L-THREONINE PRODUCTION ARCHER-DANIELS-MIDLAND COMPANY (US) 1998-02-05 WO disclosed
WO-1997027851-A1 L-HOMOSERINE AND L-HOMOSERINE LACTONE AS BACTERIOSTATIC AGENTS FOR M. TUBERCULOSIS AND M. BOVIS THE JOHNS-HOPKINS UNIVERSITY (US) 1997-08-07 WO disclosed
US-5641660-A Glutamicum threonine biosynthetic pathway MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1997-06-24 US disclosed
US-5128255-A Method and a preparation to select for transfected DNA in mammalian cells GENTEST CORPORATION (US) 1992-07-07 US disclosed