Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Homoserine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLUL | P15104 | 1/20 | 0.53 |
| ▸ | GRM8 | O00222 | 2/20 | 0.52 |
| ▸ | GRM6 | O15303 | 2/20 | 0.52 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homoserine SCHEMBL383537 | 1.00 | GLUL (0.53) | GLULGRM8GRM6GRM7GRM4 | |
| Homoserine SCHEMBL27518745 | 1.00 | GLUL (0.53) | GLULGRM8GRM6GRM7GRM4 | |
| Homoserine SCHEMBL6447119 | 0.90 | GSR (0.59) | GRM8GRM6GRM7GRM4GRIN2D | |
| Homoserine SCHEMBL29649 | 0.90 | — | — | |
| Homoserine SCHEMBL60060 | 0.90 | — | — | |
| Homoserine SCHEMBL4944178 | 0.90 | GSR (0.59) | GRM8GRM6GRM7GRM4GRIN2D | |
| Homoserine SCHEMBL6446994 | 0.90 | GSR (0.59) | GRM8GRM6GRM7GRM4GRIN2D | |
| Homoserine SCHEMBL29648 | 0.90 | — | — | |
| Homoserine SCHEMBL23748103 | 0.87 | — | — | |
| Homoserine SCHEMBL9471942 | 0.87 | GSR (0.56) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104379729-A | Useful microorganism, and method for producing desired substance | GENARIS INC | 2015-02-25 | — | — | CN | claimed |
| WO-1997027851-A1 | L-HOMOSERINE AND L-HOMOSERINE LACTONE AS BACTERIOSTATIC AGENTS FOR M. TUBERCULOSIS AND M. BOVIS | THE JOHNS-HOPKINS UNIVERSITY (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0338790-A2 | Production of homoserine and its derivatives such as threonine derivatives and methionine precursors | BIOTECHNICA INTERNATIONAL, INC. (US) | 1989-10-25 | — | — | EP | claimed |
| US-20250361531-A1 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS | AGAIN BIO APS (DK) | 2025-11-27 | — | — | US | disclosed |
| US-12312627-B2 | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds | GENOMATICA, INC. (US) | 2025-05-27 | — | — | US | disclosed |
| CN-110869503-B | Methionine producing yeast | 安迪苏法国联合股份有限公司 | 2024-09-27 | — | — | CN | disclosed |
| EP-4414451-A2 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 4 HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS | Genomatica, Inc. (US) | 2024-08-14 | — | — | EP | disclosed |
| EP-2989113-B1 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS | GENOMATICA INC (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-110869488-B | Enhanced metabolite producing yeast | 安迪苏法国联合股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| US-11932845-B2 | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds | GENOMATICA, INC. (US) | 2024-03-19 | — | — | US | disclosed |
| CN-110892073-B | Enhanced metabolite producing yeast | 安迪苏法国联合股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-7858350-B2 | Microorganisms for the production of 1,4-butanediol | GENOMATICA, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100323418-A1 | ORGANISMS FOR THE PRODUCTION OF ISOPROPANOL, n-BUTANOL, AND ISOBUTANOL | GENOMATICA, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| WO-2010141920-A2 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS | GENOMATICA, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010127303-A1 | ORGANISMS FOR THE PRODUCTION OF ISOPROPANOL, N-BUTANOL, AND ISOBUTANOL | GENOMATICA, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| US-20100112654-A1 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL | AGAIN BIO APS (DK) | 2010-05-06 | — | — | US | disclosed |
| WO-2010030711-A2 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL | GENOMATICA, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| CN-1261576-C | Escherichia coli strains and preparation thereof and use thereof in fermentation process for production of L-threonine | ARCHER DANIELS MIDLAND CO (US) | 2006-06-28 | — | — | CN | disclosed |
| CN-1226931-A | Escherichia coli strains and preparation thereof and use thereof in fermentation process for production of L-threonine | ARCHER DANIELS MIDLAND CO (US) | 1999-08-25 | — | — | CN | disclosed |
| US-5641660-A | Glutamicum threonine biosynthetic pathway | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250361531-A1 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS | HSD17B10, HSD17B12, HADHB | GLUL 899/4885GRM8 3318/4885GRM6 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.