SCHEMBL3835404

SCHEMBL3835404

CN(C)CCC(NC(=O)Nc1ccc(F)cc1)c1ccc(C(=O)Nc2ccccc2N)cc1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 11/20 0.59
UTS2R Q9UKP6 8/20 0.54
ROCK2 O75116 1/20 0.48
ROCK1 Q13464 1/20 0.48
HDAC2 Q92769 3/20 0.47
HDAC3 O15379 2/20 0.47
NCOR2 Q9Y618 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2471256 0.92 UTS2R (0.58) HDAC1UTS2RHDAC2HDAC3NCOR2
SCHEMBL2480482 0.91 UTS2R (0.55) HDAC1UTS2RROCK2ROCK1HDAC2
SCHEMBL2474090 0.89 UTS2R (0.52) HDAC1UTS2RHDAC2HDAC3NCOR2
SCHEMBL2474114 0.89 UTS2R (0.54) HDAC1UTS2R
SCHEMBL2504353 0.89 UTS2R (0.65) HDAC1UTS2RHDAC2HDAC3NCOR2
SCHEMBL2478630 0.86 HDAC1 (0.56) HDAC1UTS2RHDAC2HDAC3NCOR2
SCHEMBL3832758 0.86 UTS2R (0.49) HDAC1UTS2RHDAC2HDAC3NCOR2
SCHEMBL3834409 0.86 UTS2R (0.49) HDAC1UTS2RHDAC2HDAC3NCOR2
SCHEMBL2476211 0.85 HDAC1 (0.56) HDAC1HDAC2HDAC3NCOR2
SCHEMBL2476829 0.85 UTS2R (0.49) HDAC1UTS2RHDAC2HDAC3NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076332-B2 N- (2-aminophenyl) benzamide derivative having urea structure SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-12-13 US disclosed
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO., LTD. (JP) 2009-12-10 US disclosed
EP-2107052-A1 NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE Santen Pharmaceutical Co., Ltd (JP) 2009-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE UACA, SLC14A1, ARG2 HDAC1 200/4885UTS2R 11/4885ROCK2 499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.