Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 15/20 | 0.48 |
| ▸ | CTSL | P07711 | 13/20 | 0.48 |
| ▸ | CTSK | P43235 | 9/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291062 | 0.88 | CTSS (0.59) | CTSSCTSLCTSKRAB9ANPC1 | |
| SCHEMBL3836140 | 0.84 | CTSS (0.51) | CTSSCTSLCTSKITGB3ITGAV | |
| SCHEMBL3025210 | 0.79 | NPC1 (0.53) | CTSSCTSLCTSKRAB9ANPC1 | |
| SCHEMBL3837674 | 0.79 | CTSS (0.64) | CTSSCTSLCTSK | |
| SCHEMBL3840211 | 0.79 | CTSS (0.50) | CTSSCTSLCTSK | |
| SCHEMBL3839482 | 0.78 | CTSS (0.64) | CTSSCTSLCTSK | |
| SCHEMBL14277863 | 0.74 | RAB9A (0.62) | CTSSCTSLCTSKRAB9ANPC1 | |
| SCHEMBL3837319 | 0.72 | CTSS (0.47) | CTSSCTSLCTSK | |
| SCHEMBL8291073 | 0.72 | CTSS (0.60) | CTSSCTSLCTSK | |
| SCHEMBL12196265 | 0.69 | CTSS (0.58) | CTSSCTSLCTSKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-B1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2009-10-14 | — | — | EP | claimed |