Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039120 | 0.88 | POLB (0.58) | IMPDH2POLBKCNK9ADAMTS4ADAMTS5 | |
| SCHEMBL3836272 | 0.86 | RAB9A (0.57) | IMPDH2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL3838597 | 0.85 | IMPDH2 (0.52) | IMPDH2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL94229 | 0.85 | IMPDH2 (0.52) | IMPDH2RAB9APOLBKCNK9ADAMTS4 | |
| SCHEMBL3835811 | 0.83 | POLB (0.56) | IMPDH2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3836954 | 0.83 | IMPDH2 (0.51) | IMPDH2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3043849 | 0.83 | NPC1 (0.56) | PPARGIMPDH2MEN1KMT2ANPC1 | |
| SCHEMBL3834428 | 0.81 | ROCK2 (0.49) | IMPDH2NPC1KCNN4RAB9AALDH1A1 | |
| SCHEMBL3837433 | 0.81 | RAB9A (0.53) | IMPDH2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3860731 | 0.81 | EPHX2 (0.50) | IMPDH2RAB9AALDH1A1POLBADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |
| US-4234515-A | Preparation of N,N-difluoroamines | RESEARCH INSTITUTE FOR MEDICINE & CHEMISTRY INC. (US) | 1980-11-18 | — | — | US | disclosed |