Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835082 | 0.91 | HTR2A (0.39) | HTR2AHTR2CBRD3KDR | |
| SCHEMBL3839247 | 0.80 | PPARG (0.35) | HTR2AHTR2CKDRPTGS1PTGS2 | |
| SCHEMBL3840372 | 0.77 | PPARG (0.35) | HTR2AHTR2CKDRPTGS1PTGS2 | |
| SCHEMBL3839475 | 0.75 | TUBB4A (0.46) | HTR2AHTR2CSMN1; SMN2POLB | |
| SCHEMBL2345144 | 0.70 | MAPT (0.52) | SMN1; SMN2POLBPTGS2 | |
| SCHEMBL3839514 | 0.67 | TUBB4A (0.36) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL3835938 | 0.67 | PPARG (0.41) | POLBMAPK1PTGS1PTGS2 | |
| SCHEMBL3839592 | 0.65 | TUBB4A (0.39) | SMN1; SMN2HTR1AHTR3A | |
| SCHEMBL3837549 | 0.65 | TUBB4A (0.38) | HTR2AHTR2C | |
| SCHEMBL5354957 | 0.63 | PTGS2 (0.58) | SMN1; SMN2KIF11HTR1AHTR3APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791537-B1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2009-10-14 | — | — | EP | claimed |