Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29908914 | 0.85 | ALDH1A1 (0.55) | FFAR1MKNK1MKNK2ALDH1A1APP | |
| SCHEMBL29603820 | 0.83 | KMO (0.59) | FFAR1MKNK1MKNK2ALDH1A1APP | |
| SCHEMBL16720129 | 0.83 | KMO (0.59) | FFAR1MKNK1MKNK2ALDH1A1APP | |
| SCHEMBL13907278 | 0.83 | CYP2A6 (0.62) | FFAR1CYP2A6CYP2E1CYP3A4CYP2D6 | |
| SCHEMBL400670 | 0.82 | HDAC1 (0.60) | FFAR1HIF1AEPAS1 | |
| SCHEMBL28718553 | 0.82 | KMO (0.58) | FFAR1MKNK1MKNK2ALDH1A1APP | |
| SCHEMBL402518 | 0.81 | RARB (0.62) | FFAR1APPRARBRARGPTPN11 | |
| SCHEMBL401836 | 0.81 | GRM5 (0.64) | FFAR1APPCYP2A6CYP2E1CYP3A4 | |
| SCHEMBL31673222 | 0.81 | GRM5 (0.64) | FFAR1APPCYP2A6CYP2E1CYP3A4 | |
| SCHEMBL3838348 | 0.81 | ALDH1A1 (0.61) | FFAR1ALDH1A1HAO1CYP2A6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729771-B1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-14 | — | — | EP | claimed |