Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719847 | 0.86 | ALDH1A1 (0.52) | ALDH1A1FFAR1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3714223 | 0.85 | ALDH1A1 (0.62) | ALDH1A1CYP19A1CYP11B1CYP11B2SLC2A1 | |
| SCHEMBL3712736 | 0.85 | ALDH1A1 (0.62) | ALDH1A1CYP19A1CYP11B1CYP11B2CSF1R | |
| SCHEMBL3710033 | 0.84 | ALDH1A1 (0.54) | ALDH1A1FFAR1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL22833769 | 0.83 | CSF1R (0.68) | ALDH1A1CYP19A1CYP11B1CYP11B2SLC2A1 | |
| SCHEMBL3714187 | 0.82 | ALDH1A1 (0.51) | ALDH1A1FFAR1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL25210061 | 0.82 | PTPN11 (0.58) | ALDH1A1FFAR1PTPN11CYP2C9CYP2C19 | |
| SCHEMBL1105504 | 0.82 | TSHR (0.67) | ALDH1A1PTPN11KMT2ACYP2C9CYP2C19 | |
| SCHEMBL69268 | 0.82 | PTPN11 (0.69) | ALDH1A1PTPN11KMT2ACYP2C9CYP2C19 | |
| SCHEMBL29506324 | 0.82 | CSF1R (0.53) | ALDH1A1CYP19A1CYP11B1CYP11B2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729771-B1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-14 | — | — | EP | claimed |
| EP-1729771-B1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-14 | — | — | EP | disclosed |