Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836802 | 0.90 | PTGES (0.50) | PTGESFFAR1CYP2D6HRH3DRD2 | |
| SCHEMBL28255391 | 0.89 | FFAR1 (0.48) | PTGESGRM5FFAR1ASIC3 | |
| SCHEMBL4533749 | 0.84 | AGXT (0.52) | CTSSCTSKHRH3AGXTKIF11 | |
| SCHEMBL10078136 | 0.82 | AGXT (0.50) | CTSSCTSKHRH3AGXTKIF11 | |
| SCHEMBL3841194 | 0.81 | FFAR1 (0.44) | PTGESFFAR1CYP2D6HRH3DRD2 | |
| SCHEMBL234830 | 0.81 | MAOA (0.46) | PTGESGRM5AGXTASIC3 | |
| SCHEMBL612967 | 0.81 | PTGES (0.47) | PTGESGRM5FFAR1CYP2D6HRH3 | |
| SCHEMBL3836772 | 0.80 | AGXT (0.48) | CTSSCTSKAGXTKIF11 | |
| SCHEMBL24005570 | 0.80 | CTSS (0.50) | CTSSCTSKAGXT | |
| SCHEMBL3843357 | 0.79 | GRM5 (0.48) | PTGESGRM5FFAR1CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |