Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871750 | 0.92 | JAK2 (0.46) | JAK2KMT2AHCAR3OPRK1 | |
| SCHEMBL15635529 | 0.90 | JAK2 (0.46) | JAK2KMT2AHCAR3OPRK1MCHR1 | |
| SCHEMBL3837581 | 0.85 | OPRK1 (0.43) | JAK2KMT2AOPRK1MCHR1GPR6 | |
| SCHEMBL4100544 | 0.81 | HCAR3 (0.38) | JAK2HCAR3OPRK1GPR6ALDH1A1 | |
| SCHEMBL17110968 | 0.80 | MAPK8 (0.43) | JAK2HCAR3 | |
| SCHEMBL290570 | 0.79 | KEAP1 (0.53) | CA1CA2ALDH1A1DHODH | |
| SCHEMBL31349524 | 0.79 | KEAP1 (0.53) | CA1CA2ALDH1A1DHODH | |
| SCHEMBL27598069 | 0.79 | KEAP1 (0.53) | CA1CA2ALDH1A1DHODH | |
| SCHEMBL17363149 | 0.79 | MCHR1 (0.56) | JAK2HCAR3OPRK1CISD1CA12 | |
| SCHEMBL870326 | 0.79 | SSTR4 (0.46) | JAK2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | AstraZeneca AB (SE) | 2009-10-07 | — | — | EP | disclosed |
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |