Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.34 |
| ▸ | CTSA | P10619 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29723811 | 0.82 | KDM4E (0.70) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL107964 | 0.82 | KDM4E (0.70) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL11682457 | 0.80 | KDM4E (0.67) | KDM4EALOX15TSHRACMSDTDP1 | |
| 2-Picolinic Acid SCHEMBL2291560 | 0.76 | LMNA (0.67) | KDM4EALOX15TSHRACMSDTDP1 | |
| 2-Picolinic Acid SCHEMBL27223671 | 0.76 | LMNA (0.67) | KDM4EALOX15TSHRACMSDTDP1 | |
| Imidazole SCHEMBL15718885 | 0.75 | P2RX7 (0.44) | KDM4EALOX15TSHRACMSDTDP1 | |
| Isophthalic Acid SCHEMBL15234293 | 0.72 | KMO (0.47) | KDM4ETDP1ALDH1A1FKBP5NAPRT | |
| Benzoic Acid SCHEMBL5323571 | 0.72 | NAPRT (0.54) | KDM4ETSHRALDH1A1FKBP5NAPRT | |
| Phthalic Acid SCHEMBL2196835 | 0.72 | ALDH1A1 (0.54) | KDM4EALOX15TSHRTDP1ALDH1A1 | |
| Phthalic Acid SCHEMBL2196833 | 0.72 | ALDH1A1 (0.54) | KDM4EALOX15TSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | AstraZeneca AB (SE) | 2009-10-07 | — | — | EP | disclosed |
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |