Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | MGMT | P16455 | 3/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminopurine SCHEMBL5634 | 0.89 | ALDH1A1 (1.00) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL29056388 | 0.87 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL31379734 | 0.87 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL357699 | 0.87 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL3144589 | 0.87 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL28208518 | 0.87 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL28075430 | 0.87 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL20305132 | 0.86 | ALDH1A1 (0.79) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL8552158 | 0.86 | ALDH1A1 (0.79) | ALDH1A1RXFP1KDM4EDPP4PDPK1 | |
| 2-Aminopurine SCHEMBL6056061 | 0.85 | ALDH1A1 (0.92) | ALDH1A1RXFP1KDM4EDPP4PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318700-B2 | Lung-targeted drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-17 | — | — | US | disclosed |
| US-8101745-B2 | Conjugate cidofovir, idoxuridine, vidarabine, trifluridine, acyclovir, famciclovir penciclovir, valacyclovir, ganciclovir, antiviral, antimicrobial, cancer drug of interest to glycerol ethers or glycerol phosphate ethers | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080221061-A1 | Lung-Targeted Drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-11 | — | — | US | disclosed |
| US-5877166-A | HERPES VIRUS | SRI INTERNATIONAL (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1997041133-A1 | ENANTIOMERICALLY PURE 2-AMINOPURINE PHOSPHONATE NUCLEOTIDE ANALOGS AS ANTIVIRAL AGENTS | SRI INTERNATIONAL (US) | 1997-11-06 | — | — | WO | disclosed |
| WO-1997041133-A1 | ENANTIOMERICALLY PURE 2-AMINOPURINE PHOSPHONATE NUCLEOTIDE ANALOGS AS ANTIVIRAL AGENTS | SRI INTERNATIONAL (US) | 1997-11-06 | — | — | WO | disclosed |
| WO-1997041133-A1 | ENANTIOMERICALLY PURE 2-AMINOPURINE PHOSPHONATE NUCLEOTIDE ANALOGS AS ANTIVIRAL AGENTS | SRI INTERNATIONAL (US) | 1997-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221061-A1 | Lung-Targeted Drugs | DGKG, GK, PHOSPHO1 | ALDH1A1 4007/4885RXFP1 3459/4885KDM4E 1694/4885 |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | DGKG, GK, PHOSPHO1 | ALDH1A1 4007/4885RXFP1 3459/4885KDM4E 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.