Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Aminopurine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.44 |
| ▸ | POLA1 known ✓ | P09884 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.96 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminopurine SCHEMBL5634 | 0.98 | ALDH1A1 (1.00) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL31379734 | 0.96 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL28208518 | 0.96 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL28075430 | 0.96 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL29056388 | 0.96 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL3144589 | 0.96 | ALDH1A1 (0.96) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL6056061 | 0.94 | ALDH1A1 (0.92) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL1528159 | 0.89 | ALDH1A1 (0.82) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL8552158 | 0.87 | ALDH1A1 (0.79) | ALDH1A1RXFP1KDM4EPDPK1GDA | |
| 2-Aminopurine SCHEMBL2787175 | 0.87 | ALDH1A1 (0.79) | ALDH1A1RXFP1KDM4EPDPK1GDA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102438453-A | Plant growth regulator additive | TAMINCO NV | 2012-05-02 | — | — | CN | claimed |
| US-9334486-B2 | Nitrogen use efficient transgenic plants | AVESTHAGEN LIMITED (IN) | 2016-05-10 | — | — | US | disclosed |
| CN-102438447-A | Safening agent | TAMINCO NV | 2012-05-02 | — | — | CN | disclosed |
| CN-102438453-A | Plant growth regulator additive | TAMINCO NV | 2012-05-02 | — | — | CN | disclosed |
| US-20120017334-A1 | Nitrogen Use Efficient Transgenic Plants | AVESTHAGEN LIMITED (IN) | 2012-01-19 | — | — | US | disclosed |
| US-20110277188-A1 | Change in Plant Architecture | MORAWALA-PATELL VILLOO | 2011-11-10 | — | — | US | disclosed |
| US-20110231956-A1 | Environmentally Adjusted Transgenic Plants | AVESTHAGEN LIMITED (IN) | 2011-09-22 | — | — | US | disclosed |
| EP-2334798-A2 | GLUTAMATE DECARBOXYLASE (GAD) TRANSGENIC PLANTS THAT EXHIBIT ALTERED PLANT ARCHITECTURE | Avesthagen Limited (IN) | 2011-06-22 | — | — | EP | disclosed |
| EP-2313510-A2 | GLUTAMATE DECARBOXYLASE (GAD) TRANSGENIC PLANTS WITH ENHANCED NITROGEN UPTAKE AND UTILISATION | Avesthagen Limited (IN) | 2011-04-27 | — | — | EP | disclosed |
| EP-2312934-A2 | STRESS TOLERANT TRANSGENIC PLANTS | Avesthagen Limited (IN) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010007495-A2 | ENVIRONMENTALLY ADJUSTED TRANSGENIC PLANTS | AVESTHAGEN LIMITED (IN) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007496-A2 | NITROGEN USE EFFICIENT TRANSGENIC PLANTS | AVESTHAGEN LIMITED (IN) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007497-A2 | CHANGE IN PLANT ARCHITECTURE | AVESTHAGEN LIMITED (IN) | 2010-01-21 | — | — | WO | disclosed |