Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 3/20 | 0.56 |
| ▸ | FEN1 | P39748 | 3/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644722 | 0.86 | ERCC1 (0.57) | ERCC1FEN1ERCC4KDM4EMCL1 | |
| SCHEMBL3833902 | 0.82 | ERCC1 (0.60) | ERCC1FEN1ERCC4KDM4EADORA3 | |
| SCHEMBL5121410 | 0.82 | ERCC1 (0.50) | ERCC1FEN1ERCC4KDM4EADORA3 | |
| SCHEMBL5128689 | 0.80 | HPGDS (0.59) | ERCC1FEN1ERCC4KDM4EMEN1 | |
| SCHEMBL5139628 | 0.79 | LMNA (0.63) | ERCC1FEN1ERCC4KDM4EADORA2A | |
| SCHEMBL5123552 | 0.78 | SMN1; SMN2 (0.61) | ERCC1FEN1ERCC4KDM4EMEN1 | |
| SCHEMBL5121871 | 0.77 | KMT2A (0.48) | ERCC1FEN1ERCC4KDM4EADORA3 | |
| SCHEMBL5121239 | 0.77 | MEN1 (0.57) | ERCC1FEN1ERCC4KDM4EADORA2A | |
| SCHEMBL5119546 | 0.77 | MEN1 (0.57) | ERCC1FEN1ERCC4KDM4EADORA2A | |
| SCHEMBL5127508 | 0.77 | MEN1 (0.57) | ERCC1FEN1ERCC4KDM4EADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | claimed |
| EP-2639226-B1 | Anti-infective pyrimidines and uses thereof | ABBVIE BAHAMAS LTD (BS) | 2016-08-31 | — | — | EP | disclosed |
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |
| US-7091209-B2 | Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors | MERCK & CO., INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20040106627-A1 | Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECULARE P ANGELETTI SPA (IT) | 2004-06-03 | — | — | US | disclosed |
| EP-1309566-A1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002006246-A1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106627-A1 | Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors | DPYD, DUT, UMPS | ERCC1 2410/4885FEN1 807/4885ERCC4 1146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.