Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10430736 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL2143227 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL8402278 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL13020456 | 0.95 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL57036 | 0.95 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL890725 | 0.91 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL4951882 | 0.89 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL4815560 | 0.89 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL8484861 | 0.89 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL8483813 | 0.89 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11434203-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2022-09-06 | — | — | US | disclosed |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2021-01-28 | — | — | US | disclosed |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-22 | — | — | US | disclosed |
| US-20180327362-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2018-11-15 | — | — | US | disclosed |
| US-9839701-B2 | Aromatic amino acid derivative and positron emission topography (PET) probe using the same | OSAKA UNIVERSITY (JP) | 2017-12-12 | — | — | US | disclosed |
| WO-2017027064-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-16 | — | — | WO | disclosed |
| US-20160038620-A1 | AROMATIC AMINO ACID DERIVATIVE AND POSITRON EMISSION TOPOGRAPHY (PET) PROBE USING THE SAME | NARD INSTITUTE, LTD. (JP) | 2016-02-11 | — | — | US | disclosed |
| EP-2957556-A1 | AROMATIC AMINO ACID DERIVATIVE AND POSITRON EMISSION TOPOGRAPHY (PET) PROBE UTILIZING SAME | Osaka University (JP) | 2015-12-23 | — | — | EP | disclosed |
| US-20090260971-A1 | METHOD OF PREPARING FLUOROALKYL COMPOUNDS USING RADIATION | KOREA ATOMIC ENERGY RESEARCH INSTITUTE (KR) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11434203-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | KLK3, COQ8A, PARK7 | ALDH1A1 1333/4885CYP3A4 876/4885CYP2C9 1706/4885 |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | KLK3, COQ8A, PARK7 | ALDH1A1 1333/4885CYP3A4 876/4885CYP2C9 1706/4885 |
| US-20180327362-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | KLK3, COQ8A, PARK7 | ALDH1A1 1333/4885CYP3A4 876/4885CYP2C9 1706/4885 |
| US-20160038620-A1 | AROMATIC AMINO ACID DERIVATIVE AND POSITRON EMISSION TOPOGRAPHY (PET) PROBE USING THE SAME | SLC7A1, SLC43A1, LATS1 | ALDH1A1 2352/4885CYP3A4 2990/4885CYP2C9 3300/4885 |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | KLK3, COQ8A, PARK7 | ALDH1A1 1333/4885CYP3A4 876/4885CYP2C9 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.