SCHEMBL3839397

SCHEMBL3839397

CC1(NCc2cc(I)c3c(c2)CNC3=O)CCCCC1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.33
KDR P35968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3836956 0.78 SLC2A1 (0.35)
SCHEMBL3835531 0.72 GSR (0.35) PDGFRBKDR
SCHEMBL3836776 0.71 AURKA (0.34) KDR
SCHEMBL3837174 0.71 KDR (0.34) KDR
SCHEMBL30605905 0.71 CLK4 (0.40) PDGFRBKDR
SCHEMBL3835406 0.71 PARP1 (0.45)
SCHEMBL3839331 0.71 KDR (0.32) KDR
SCHEMBL3834497 0.70 PARP1 (0.47) KDR
SCHEMBL3837307 0.70 ADRA2C (0.44) PDGFRBKDR
SCHEMBL25414903 0.69 PIM1 (0.38) PDGFRBKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2108642-A1 JAK INHIBITOR Kyowa Hakko Kirin Co., Ltd. (JP) 2009-10-14 EP disclosed