Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | ADK | P55263 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.43 |
| ▸ | TUBB | P07437 | 5/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526599 | 0.87 | GSK3B (0.56) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL3839803 | 0.86 | TUBB4A (0.44) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL3838681 | 0.84 | KIF11 (0.42) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL3837499 | 0.84 | HTR6 (0.41) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL3836337 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL3839787 | 0.82 | SCN9A (0.43) | KDM4EALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL9573791 | 0.80 | TUBB4A (0.46) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL4208427 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL3835352 | 0.79 | HSD17B10 (0.48) | KDM4EALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL2348968 | 0.78 | MAP2 (0.55) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791537-B1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2009-10-14 | — | — | EP | claimed |