Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ADK | P55263 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839795 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1HPGDGSK3BADK | |
| SCHEMBL3837499 | 0.80 | HTR6 (0.41) | KDM4EALDH1A1HPGDGSK3BADK | |
| SCHEMBL3838681 | 0.80 | KIF11 (0.42) | KDM4EALDH1A1HPGDGSK3BADK | |
| SCHEMBL2351116 | 0.79 | MAP2 (0.51) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL3839787 | 0.78 | SCN9A (0.43) | KDM4EALDH1A1HPGDGSK3BADK | |
| SCHEMBL3839803 | 0.77 | TUBB4A (0.44) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL3835352 | 0.75 | HSD17B10 (0.48) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL7594375 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL3839281 | 0.74 | KDM4E (0.39) | KDM4EALDH1A1HPGDGSK3BADK | |
| SCHEMBL3834645 | 0.74 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDGSK3BADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791537-B1 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2009-10-14 | — | — | EP | claimed |