Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048705 | 0.86 | GPR132 (0.51) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL3049111 | 0.81 | ROCK2 (0.51) | KDM4EALDH1A1LMNAROCK2ROCK1 | |
| SCHEMBL3046878 | 0.81 | ROCK2 (0.56) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL3039175 | 0.80 | ROCK2 (0.47) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL3039120 | 0.79 | POLB (0.58) | SMN1; SMN2POLBROCK2ROCK1IMPDH2 | |
| SCHEMBL3834428 | 0.79 | ROCK2 (0.49) | ALDH1A1LMNARAB9APOLBNPC1 | |
| SCHEMBL3042553 | 0.78 | ROCK2 (0.48) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL3836272 | 0.78 | RAB9A (0.57) | ALDH1A1LMNARAB9APOLBNPC1 | |
| SCHEMBL3046859 | 0.78 | ROCK2 (0.48) | ROCK2ROCK1IMPDH2ADAMTS4ADAMTS5 | |
| SCHEMBL94229 | 0.76 | IMPDH2 (0.52) | SMN1; SMN2LMNARAB9APOLBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |