Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052162 | 0.86 | LMNA (0.43) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL3841049 | 0.84 | FFAR1 (0.49) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL3839635 | 0.79 | FFAR1 (0.45) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL21312768 | 0.75 | FFAR1 (0.56) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL21312521 | 0.72 | FFAR1 (0.53) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL7498591 | 0.71 | NPC1 (0.44) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL8043911 | 0.71 | TARBP2 (0.46) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL7504854 | 0.68 | CYP2E1 (0.52) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL2010909 | 0.68 | FFAR1 (0.50) | FFAR1CYP2C9MAPTGAANPC1 | |
| SCHEMBL8035014 | 0.68 | TARBP2 (0.42) | FFAR1CYP1A2CYP2E1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861247-B1 | NOVEL IMIDAZOLE N-BENZYLDIOXOL DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2009-10-07 | — | — | EP | disclosed |