Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 11/20 | 0.41 |
| ▸ | RXRA | P19793 | 10/20 | 0.41 |
| ▸ | RXRG | P48443 | 9/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839624 | 0.80 | LMNA (0.34) | RXRBRXRARXRGBRD4MAPT | |
| SCHEMBL3592575 | 0.74 | RXRB (0.43) | RXRBRXRARXRGPPARDPPARG | |
| SCHEMBL3841406 | 0.73 | RXRB (0.41) | RXRBRXRARXRGPPARDPPARG | |
| SCHEMBL5833502 | 0.71 | RXRA (0.49) | RXRBRXRARXRGPPARDPPARG | |
| SCHEMBL25732360 | 0.69 | RXRB (0.49) | RXRBRXRARXRGPPARDPPARG | |
| SCHEMBL1356087 | 0.68 | LIPE (0.58) | RXRBRXRARXRGPPARDPPARG | |
| SCHEMBL10853603 | 0.66 | MAOB (0.55) | RXRBRXRARXRG | |
| SCHEMBL3371584 | 0.65 | RXRB (0.49) | RXRBRXRARXRGPPARDPPARG | |
| SCHEMBL16347731 | 0.65 | RAB9A (0.46) | RXRBRXRARXRGMAPTSMN1; SMN2 | |
| SCHEMBL22163922 | 0.64 | MRGPRX4 (0.46) | BRD4MRGPRX4MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108019-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094575-A2 | 1-H-PYRAZOLO(3,4B)PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |