Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846364 | 0.83 | IDO1 (0.46) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL3841735 | 0.81 | PTPN1 (0.46) | ALDH1A1NPC1KDM4EKMT2AMAPT | |
| SCHEMBL3843553 | 0.72 | ERCC1 (0.43) | ALDH1A1SMN1; SMN2HPGDKDM4EKMT2A | |
| SCHEMBL2731878 | 0.66 | NPC1 (0.68) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL4889367 | 0.65 | EGLN1 (0.40) | ALDH1A1RAB9ALMNAHDAC3HDAC1 | |
| SCHEMBL2027869 | 0.65 | MCL1 (0.70) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL10062922 | 0.63 | ITK (0.67) | ALDH1A1SMN1; SMN2RAB9AKDM4EKMT2A | |
| SCHEMBL8054368 | 0.62 | MTNR1A (0.75) | — | |
| SCHEMBL12191001 | 0.62 | RAB9A (0.56) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL20792473 | 0.62 | RAB9A (0.57) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114898-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | Amgen Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008103277-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | AMGEN INC. (US) | 2008-08-28 | — | — | WO | disclosed |