Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841574 | 0.81 | ALDH1A1 (0.43) | PTPN1ALDH1A1KDM4EKMT2AHTR1D | |
| SCHEMBL3846364 | 0.72 | IDO1 (0.46) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL5183298 | 0.69 | KDM4E (0.52) | ALDH1A1KDM4ERXFP1FEN1 | |
| SCHEMBL6516216 | 0.69 | LTA4H (0.59) | ALDH1A1PPARGKDM4ENCOA2NCOA1 | |
| SCHEMBL6393707 | 0.69 | FFAR1 (0.57) | ALDH1A1PPARGKDM4ENCOA2NCOA1 | |
| SCHEMBL4048685 | 0.68 | LTA4H (0.54) | PTPN1ALDH1A1PPARGKDM4ENCOA2 | |
| SCHEMBL5053028 | 0.68 | ALDH1A1 (0.47) | PTPN1ALDH1A1PPARGKDM4ENCOA2 | |
| SCHEMBL352568 | 0.68 | ALDH1A1 (0.47) | PTPN1ALDH1A1PPARGKDM4ENCOA2 | |
| SCHEMBL3844258 | 0.67 | ERCC1 (0.50) | ALDH1A1KDM4EMEN1KMT2AERCC1 | |
| SCHEMBL9450326 | 0.66 | ALDH1A1 (0.44) | ALDH1A1PPARGKDM4ENCOA2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114898-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | Amgen Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008103277-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | AMGEN INC. (US) | 2008-08-28 | — | — | WO | disclosed |