Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844306 | 0.79 | IDO1 (0.48) | MTNR1AMTNR1BKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3844258 | 0.75 | ERCC1 (0.50) | ERCC1ERCC4KDM4EALDH1A1PKM | |
| SCHEMBL25420774 | 0.73 | EPHX2 (0.51) | ERCC1ERCC4ALDH1A1PKMHPGD | |
| SCHEMBL15816176 | 0.72 | ERCC1 (0.55) | ERCC1ERCC4KDM4EALDH1A1PKM | |
| SCHEMBL3841574 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL11080741 | 0.71 | MTNR1A (0.78) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL17546137 | 0.70 | ERCC1 (0.52) | ERCC1ERCC4ALDH1A1PKMHPGD | |
| SCHEMBL13729262 | 0.70 | CREBBP (0.47) | ERCC1ERCC4PKMKMT2AMEN1 | |
| SCHEMBL1157319 | 0.69 | NPC1 (0.38) | MTNR1AMTNR1BALDH1A1PKMHPGD | |
| SCHEMBL2635629 | 0.68 | DAO (0.43) | ERCC1ERCC4PKMDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114898-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | Amgen Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008103277-A2 | NITROGEN-CONTAINING HETEROCYCLYL KETONES AND THEIR USE AS C-MET INHIBITORS | AMGEN INC. (US) | 2008-08-28 | — | — | WO | disclosed |