Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849928 | 0.96 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL3848685 | 0.92 | AGTR1 (0.49) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7883547 | 0.91 | AGTR1 (0.38) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7428535 | 0.90 | AGTR1 (0.46) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL668740 | 0.89 | AGTR1 (0.55) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL668741 | 0.89 | AGTR1 (0.44) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7887910 | 0.88 | AGTR1 (0.36) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL3842922 | 0.88 | AGTR2 (0.55) | AGTR1AGTR2 | |
| SCHEMBL7438005 | 0.85 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL668511 | 0.85 | AGTR1 (0.51) | AGTR1AGTR2ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1884240-B1 | PHARMACEUTICAL FOR PREVENTION OR TREATMENT OF BONE METABOLIC DISEASE | DAIICHI SANKYO CO LTD (JP) | 2009-11-11 | — | — | EP | claimed |
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | claimed |