Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836970 | 0.81 | GGPS1 (0.42) | TAAR1AKT1GGPS1MAPK1L3MBTL1 | |
| SCHEMBL3840901 | 0.79 | HTR6 (0.34) | TAAR1MAOA | |
| SCHEMBL3837370 | 0.77 | TAAR1 (0.41) | TAAR1AKT1ACHEMAPK1L3MBTL1 | |
| SCHEMBL3228373 | 0.76 | TAAR1 (0.51) | TAAR1AKT1MAPK1L3MBTL1TSHR | |
| SCHEMBL609886 | 0.74 | TAAR1 (0.44) | TAAR1GGPS1ACHEMAPK1L3MBTL1 | |
| SCHEMBL235966 | 0.73 | TAAR1 (0.42) | TAAR1LTA4H | |
| SCHEMBL3862238 | 0.72 | TAAR1 (0.40) | TAAR1GGPS1ACHE | |
| SCHEMBL3841016 | 0.71 | TRPA1 (0.53) | TAAR1AKT1GGPS1MAPK1L3MBTL1 | |
| SCHEMBL14191952 | 0.69 | TAAR1 (0.50) | TAAR1MAPK1L3MBTL1TSHR | |
| SCHEMBL612001 | 0.69 | TAAR1 (0.47) | TAAR1GGPS1ACHELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |