Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GRM6 | O15303 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15481445 | 0.88 | ALDH1A1 (0.47) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL1752471 | 0.86 | GCGR (0.57) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL4787798 | 0.86 | GCGR (0.43) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL3206 | 0.85 | GCGR (0.47) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL2211 | 0.84 | ALDH1A1 (0.47) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL3589 | 0.84 | ALDH1A1 (0.44) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL8199366 | 0.84 | ALDH1A1 (0.44) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL9562753 | 0.83 | ADORA3 (0.52) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2768 | 0.83 | PTGS2 (0.53) | PRKCZMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL6082682 | 0.82 | ADORA2A (0.44) | GCGRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273878-B2 | Process for the preparation of pyrimidine compounds | ASTRAZENECA UK LIMITED (GB) | 2012-09-25 | — | — | US | disclosed |
| EP-1578731-B1 | PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2009-11-11 | — | — | EP | disclosed |
| US-20090264654-A1 | PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2009-10-22 | — | — | US | disclosed |
| EP-2088142-A2 | Compounds and Processes | AstraZeneca UK Limited (GB) | 2009-08-12 | — | — | EP | disclosed |
| US-7524955-B2 | Process for the preparation of pyrimidine compounds | ASTRAZENECA UK LIMITED (GB) | 2009-04-28 | — | — | US | disclosed |
| US-20060052604-A1 | Process for the Preparation of Pyrimidine Compounds | ASTRAZENECA UK LIMITED (GB) | 2006-03-09 | — | — | US | disclosed |
| EP-1578731-A2 | PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004054986-A2 | PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264654-A1 | PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS | DPYD, RIOX2, CCNE1 | PRKCZ 4365/4885MAPT 4839/4885KDM4E 640/4885 |
| US-20060052604-A1 | Process for the Preparation of Pyrimidine Compounds | DPYD, RIOX2, CCNE1 | PRKCZ 4361/4885MAPT 4836/4885KDM4E 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.