Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15481445 | 0.87 | ALDH1A1 (0.47) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL3843460 | 0.85 | PRKCZ (0.52) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL8199366 | 0.83 | ALDH1A1 (0.44) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL3589 | 0.83 | ALDH1A1 (0.44) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL8178136 | 0.83 | GCGR (0.64) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL2211 | 0.83 | ALDH1A1 (0.47) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL9562753 | 0.82 | ADORA3 (0.52) | ALDH1A1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL2768 | 0.82 | PTGS2 (0.53) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL13847943 | 0.81 | GCGR (0.43) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 | |
| SCHEMBL7922156 | 0.81 | ALDH1A1 (0.43) | GCGRTRPM8GRM6ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37314-E1 | Pyrimidine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| US-5260440-A | Anticholesterol agents | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| EP-0521471-A1 | Pyrimidine derivatives as HMG-CoA reductase inhibitors | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-01-07 | — | — | EP | disclosed |