Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 5/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 4/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847577 | 0.88 | SLC40A1 (0.39) | PARP1PARP2KCNH2SLC40A1EGFR | |
| SCHEMBL3957511 | 0.76 | BACE1 (0.34) | CCNT1CDK9BACE1BACE2PARP1 | |
| SCHEMBL3838947 | 0.72 | MPO (0.40) | PARP1PARP2KCNH2SLC40A1EGFR | |
| SCHEMBL3847249 | 0.69 | HRH4 (0.42) | PARP1PARP2KCNH2EGFRHRH4 | |
| SCHEMBL19494664 | 0.68 | CACNA1H (0.55) | SLC40A1KDM4EALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL22481384 | 0.63 | LMNA (0.45) | BACE1BACE2PARP1HRH4HRH3 | |
| SCHEMBL29668194 | 0.63 | LMNA (0.45) | BACE1BACE2PARP1HRH4HRH3 | |
| SCHEMBL22481483 | 0.63 | LMNA (0.45) | BACE1BACE2PARP1HRH4HRH3 | |
| SCHEMBL22481386 | 0.63 | LMNA (0.45) | BACE1BACE2PARP1HRH4HRH3 | |
| SCHEMBL27805787 | 0.62 | EGFR (0.46) | EGFRKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |