Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 7/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843563 | 0.88 | CCNT1 (0.39) | SLC40A1PRMT5WDR77HRH4HRH3 | |
| SCHEMBL3838947 | 0.83 | MPO (0.40) | SLC40A1PRMT5WDR77HRH4HRH3 | |
| SCHEMBL3847249 | 0.74 | HRH4 (0.42) | HRH4HRH3PARP1PARP2KCNH2 | |
| SCHEMBL4306112 | 0.73 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL5047682 | 0.70 | CCR3 (0.41) | LMNA | |
| SCHEMBL4758202 | 0.68 | POLB (0.43) | KCNH2EGFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5047886 | 0.66 | SIGMAR1 (0.38) | HRH4HRH3PARP1PARP2KCNH2 | |
| SCHEMBL4439862 | 0.66 | POLB (0.43) | KCNH2EGFRKDM4EALDH1A1HPGD | |
| SCHEMBL5048771 | 0.65 | KCNH2 (0.46) | PARP1PARP2KCNH2EGFRTNKS | |
| SCHEMBL27805787 | 0.64 | EGFR (0.46) | MPOEGFRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |