Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1919948 | 0.84 | ALDH1A1 (0.43) | ELANERPS6KA5ALDH1A1KDM4ETDP1 | |
| SCHEMBL8138907 | 0.73 | TUBB4A (0.44) | RPS6KA5KDM4CALDH1A1KDM4EMEN1 | |
| SCHEMBL1921116 | 0.70 | MAP2K1 (0.43) | CYP2C9 | |
| SCHEMBL14160373 | 0.69 | ELANE (0.32) | ELANEKDM4CKDM5AKDM5B | |
| SCHEMBL28635648 | 0.69 | RPS6KA5 (0.48) | RPS6KA5ALDH1A1L3MBTL1CYP3A4CYP2C9 | |
| SCHEMBL3777989 | 0.68 | MAP2K2 (0.37) | ELANEKDM4CKDM5AKDM5B | |
| SCHEMBL9051924 | 0.67 | KDM4E (0.60) | ELANEKDM4CALDH1A1KDM4EMEN1 | |
| SCHEMBL11480444 | 0.63 | KDM5A (0.47) | ALDH1A1KDM4EMEN1KMT2APADI4 | |
| SCHEMBL19743052 | 0.63 | ALDH1A1 (0.50) | RPS6KA5ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL21482571 | 0.62 | MEN1 (0.55) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099796-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008067481-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-05 | — | — | WO | disclosed |