SCHEMBL535347

SCHEMBL535347

O=C(O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 3/20 0.49
KDM4E B2RXH2 2/20 0.46
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
GRN P28799 1/20 0.43
SORT1 Q99523 1/20 0.43
TRPV1 Q8NER1 6/20 0.40
TRPA1 O75762 2/20 0.40
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
NR3C2 P08235 1/20 0.37
OPRL1 P41146 1/20 0.37
MALT1 Q9UDY8 1/20 0.36
RORC P51449 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL536232 0.99 KLKB1 (0.48) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL114535 0.90 KDM4E (0.49) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL30863652 0.90 KDM4E (0.49) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL15272015 0.89 KDM4E (0.48) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL354326 0.89 KDM4E (0.45) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL29488448 0.89 KDM4E (0.48) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL13483398 0.87 GRN (0.59) KDM4EGRNSORT1TRPV1TRPA1
SCHEMBL3276600 0.86 KLKB1 (0.50) KLKB1KDM4EMEN1ALDH1A1MAPT
SCHEMBL951365 0.84 TRPA1 (0.36) KLKB1GRNSORT1TRPV1TRPA1
SCHEMBL384545 0.83 KDM4E (0.42) KLKB1KDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080275065-A1 Novel Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2008-11-06 US claimed
CN-101061110-A Novel insecticides SYNGENTA PARTICIPATIONS AG (CH) 2007-10-24 CN claimed
US-20070244117-A1 Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof LEO PHARMA A/S (DK) 2007-10-18 US claimed
US-20240251795-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR SYNGENTA CROP PROTECTION AG (CH) 2024-08-01 US disclosed
EP-4387449-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR Syngenta Crop Protection AG (CH) 2024-06-26 EP disclosed
EP-4376616-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR Syngenta Crop Protection AG (CH) 2024-06-05 EP disclosed
CN-118076228-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-05-24 CN disclosed
CN-113896712-B Diamide compound containing cyclic amino acid 华东理工大学 2024-04-09 CN disclosed
CN-117813006-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-04-02 CN disclosed
CN-117715523-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-03-15 CN disclosed
WO-2023110710-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR SYNGENTA CROP PROTECTION AG (CH) 2023-06-22 WO disclosed
WO-2003027099-A1 ARTHROPODICIDAL ANTHRANILAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2003-04-03 WO disclosed
WO-2003026415-A2 INSECTICIDAL DIAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-04-03 WO disclosed
WO-2003024222-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 2003-03-27 WO disclosed
WO-2003015518-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed
WO-2003015519-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed
WO-2003016284-A1 SUBSTITUTED ANTHRANILAMIDES FOR CONTROLLING INVERTEBRATE PESTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed
WO-2003016304-A1 ORTHO-HETEROCYCLIC SUBSTITUTED ARYL AMIDES FOR CONTROLLING INVERTEBRATE PESTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed
WO-2003000669-A1 2-(2,6-DISUBSTITUTED PHENYL)-4-ARYL-5-ALKYL-1,3-OXAZOLINE COMPOUNDS USEFUL AS INSECTICIDES AND ACARICIDES DOW AGROSCIENCES LLC (US) 2003-01-03 WO disclosed
WO-2002070483-A1 HETEROCYCLIC DIAMIDE INVERTEBRATE PEST CONTROL AGENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2002-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080275065-A1 Novel Insecticides DDT, ACHE, CYP4F11 KLKB1 4563/4885KDM4E 2414/4885MEN1 1175/4885
US-20070244117-A1 Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof F9, F12, HDAC9 KLKB1 2079/4885KDM4E 843/4885MEN1 3428/4885
US-20240251795-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR DDT, NOS1, SLC11A2 KLKB1 4334/4885KDM4E 2663/4885MEN1 1173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.