Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847649 | 0.90 | KDM4E (0.39) | TGFBR1METMAPK1 | |
| SCHEMBL3871629 | 0.85 | ALDH1A1 (0.44) | TGFBR1METMAPK1 | |
| SCHEMBL3847097 | 0.83 | PRMT5 (0.38) | METPDE10AAXLKCNH2 | |
| SCHEMBL3846968 | 0.78 | KCNH2 (0.44) | TGFBR1KCNH2 | |
| SCHEMBL13874492 | 0.77 | MET (0.36) | TGFBR1METPDE10AAXLKCNH2 | |
| SCHEMBL3851820 | 0.76 | PIK3CD (0.40) | TGFBR1MET | |
| SCHEMBL3852869 | 0.75 | TGFBR1 (0.38) | TGFBR1 | |
| SCHEMBL3847846 | 0.75 | FYN (0.45) | — | |
| SCHEMBL3845550 | 0.75 | FLT3 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL6637293 | 0.74 | ALDH1A1 (0.41) | TGFBR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |