⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340809 | 0.66 | JAK2 (0.34) | — | |
| SCHEMBL8667325 | 0.66 | PNP (0.38) | — | |
| SCHEMBL3845992 | 0.63 | RXFP1 (0.31) | — | |
| SCHEMBL8667323 | 0.63 | PNP (0.53) | — | |
| SCHEMBL3845989 | 0.58 | JAK2 (0.32) | — | |
| SCHEMBL3694622 | 0.56 | — | — | |
| SCHEMBL9470564 | 0.54 | HPRT1 (0.44) | — | |
| SCHEMBL9470349 | 0.54 | LMNA (0.39) | — | |
| SCHEMBL8340807 | 0.53 | PNP (0.33) | — | |
| SCHEMBL10629392 | 0.51 | KDM4E (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592397-B2 | Compositions and methods for combination antiviral therapy | GILEAD SCIENCES, INC. (US) | 2013-11-26 | — | — | US | disclosed |
| EP-1828145-A4 | 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | UNIV EMORY (US) | 2009-08-19 | — | — | EP | disclosed |
| US-20090143314-A1 | COMPOSITIONS AND METHODS FOR COMBINATION ANTIVIRAL THERAPY | GILEAD SCIENCES, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| EP-1828145-A2 | 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | EMORY UNIVERSITY (US) | 2007-09-05 | — | — | EP | disclosed |
| US-20060246130-A1 | Compositions and methods for combination antiviral therapy | GILEAD SCIENCES, INC. | 2006-11-02 | — | — | US | disclosed |
| WO-2006063281-A2 | 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | EMORY UNIVERSITY (US) | 2006-06-15 | — | — | WO | disclosed |