Sugi Predict

Sugi Predict / Compounds / SCHEMBL3846076

SCHEMBL3846076

SCHEMBL3846076

COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1cc(C(=O)N(C)CCN(C)C)n(C)c1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKCA P17252 6/20 0.36
▸ TP53 P04637 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ THRB P10828 1/20 0.34
▸ BLM P54132 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ RXRA P19793 1/20 0.34
▸ PDGFRB P09619 3/20 0.33
▸ PDGFRA P16234 3/20 0.33
▸ FLT1 P17948 3/20 0.33
▸ KDR P35968 3/20 0.33
▸ FGFR1 P11362 2/20 0.33
▸ FGFR3 P22607 2/20 0.33
▸ KMT2A Q03164 1/20 0.32
▸ CTDSP1 Q9GZU7 1/20 0.32
▸ ADORA2A P29274 1/20 0.32
▸ ADORA1 P30542 1/20 0.32
▸ CHEK1 O14757 1/20 0.32
▸ DAPK3 O43293 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5857822 0.89 PRKCA (0.32) PRKCATP53POLBTHRBBLM
SCHEMBL3933498 0.89 PRKCA (0.32) PRKCATP53POLBTHRBBLM
SCHEMBL3934911 0.89 ITK (0.34) PRKCATP53POLBTHRBBLM
SCHEMBL3934915 0.89 ITK (0.34) PRKCATP53POLBTHRBBLM
SCHEMBL3932056 0.89 OGA (0.33) PRKCATP53POLBFGFR3KMT2A
SCHEMBL5858902 0.89 OGA (0.33) PRKCATP53POLBFGFR3KMT2A
SCHEMBL6629890 0.88 PRKCA (0.34) PRKCAADORA2AADORA1ABL1
SCHEMBL3938575 0.88 RXFP1 (0.35) TP53POLBKMT2AALDH1A1
SCHEMBL3938578 0.88 RXFP1 (0.35) TP53POLBKMT2AALDH1A1
SCHEMBL3933021 0.88 RAB9A (0.38) L3MBTL1KMT2AALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1830842-B1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INT (DE) 2009-04-22 — — EP disclosed
US-20090048267-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-02-19 — — US disclosed
US-20060154939-A1 Medicaments for the Treatment or Prevention of Fibrotic Diseases BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-07-13 — — US disclosed
US-6858641-B2 Substituted indolinones BOEHRINGER INGELHEIM PHARMA KG (DE) 2005-02-22 — — US disclosed
US-20030092756-A1 Substituted indolinones BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2003-05-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030092756-A1 Substituted indolinones CDK1, CDK2, CDKL1 PRKCA 1150/4885TP53 1204/4885POLB 1808/4885
US-20060154939-A1 Medicaments for the Treatment or Prevention of Fibrotic Diseases MMP1, COL1A1, FOXM1 PRKCA 3145/4885TP53 2283/4885POLB 4243/4885
US-20090048267-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES COL1A1, MMP1, FOXM1 PRKCA 3118/4885TP53 2424/4885POLB 4391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.