Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 5/20 | 0.33 |
| ▸ | AKT2 | P31751 | 5/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850259 | 0.83 | — | — | |
| SCHEMBL3846702 | 0.80 | RORC (0.39) | MAPK14CSNK1DMAPK11CSNK1E | |
| SCHEMBL13874308 | 0.77 | FLT3 (0.34) | FLT3AKT1AKT2NR1H4MAPK14 | |
| SCHEMBL3848664 | 0.73 | PTGS2 (0.32) | MAPK14CSNK1DMAPK11CSNK1EPTGS2 | |
| SCHEMBL3845976 | 0.73 | TGFBR1 (0.40) | FLT3MAPK14 | |
| SCHEMBL3846787 | 0.71 | POLB (0.39) | NR1H4KDM4EALDH1A1MAPK14PTGS2 | |
| SCHEMBL3846676 | 0.71 | ADORA2A (0.36) | AKT1AKT2KDM4EALDH1A1MAPK14 | |
| SCHEMBL3847341 | 0.71 | TGFBR1 (0.48) | — | |
| SCHEMBL3845245 | 0.71 | FLT3 (0.39) | FLT3AKT1AKT2MAPK14CSNK1D | |
| SCHEMBL3848105 | 0.70 | FLT3 (0.44) | FLT3AKT1AKT2MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |