Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.67 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262239 | 1.00 | CYP3A4 (0.67) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL1581156 | 1.00 | CYP3A4 (0.67) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27541751 | 0.98 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7321531 | 0.98 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1532534 | 0.98 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27415903 | 0.98 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Histidine SCHEMBL27489002 | 0.93 | CYP3A4 (0.76) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Histidine SCHEMBL27511747 | 0.93 | CYP3A4 (0.76) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL388562 | 0.89 | CYP3A4 (0.73) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL163444 | 0.87 | CYP3A4 (0.71) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023238167-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING CORONAVIRUS DISEASE AND METHODS OF PREPARATION THEREOF | APPLIED SCIENCE PRIVATE UNIVERSITY (JO) | 2023-12-14 | — | — | WO | disclosed |
| WO-2021107122-A1 | HYPOXIA RESPONSE CONTROL BY SPECIFIC AMINO ACID OR AMINO ACID-LIKE SUBSTANCE | 学校法人慶應義塾 | 2021-06-03 | — | — | WO | disclosed |
| US-9918964-B2 | Reducing platelet activation, aggregation and platelet-stimulated thrombosis or blood coagulation by reducing mitochondrial respiration | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-03-20 | — | — | US | disclosed |
| EP-2035444-B1 | DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE | FLAMMA SPA (IT) | 2015-09-02 | — | — | EP | disclosed |
| US-20110301180-A1 | Reducing Platelet Activation, Aggregation and Platelet-Stimulated Thrombosis or Blood Coagulation by Reducing Mitochondrial Respiration | STANFORD UNIVERSITY (US) | 2011-12-08 | — | — | US | disclosed |
| US-20090306165-A1 | DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE | FLAMMA S.P.A. (IT) | 2009-12-10 | — | — | US | disclosed |
| EP-1311488-B1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LTD (GB) | 2009-11-04 | — | — | EP | disclosed |
| US-6960587-B2 | Condensed pyrazindione derivatives as PDE inhibitors | LILLY ICOS LLC (US) | 2005-11-01 | — | — | US | disclosed |
| US-6949577-B2 | Pharmaceuticals | PFIZER, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1366050-B1 | CONDENSED PYRAZINDIONE DERIVATIVES AS PDE INHIBITORS | LILLY ICOS LLC (US) | 2005-04-13 | — | — | EP | disclosed |
| US-4772721-A | INTERMEDIATES FOR PROTEINS, ENZYMES | DIAMALT AG (DE) | 1988-09-20 | — | — | US | disclosed |
| US-4723027-A | TREATING AN ALDEHYDE WITH HYDROGEN CYANIDE IN THE PRESENCE OF CYCLO(D-PHENYLALANYL-D-HISTIDINE)CATALYST | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-02-02 | — | — | US | disclosed |
| US-4681947-A | NONSYMMETRICAL KETENE, ALPHA-HYDROXY NITRILE OR ALDEHYDE AND CYANIDE, CYCLO(D-PHENYLALANYL-D-HISTADINE) | E.I. DU PONT DE NEMOURS AND COMPANY | 1987-07-21 | — | — | US | disclosed |
| US-4594196-A | Reacting corresponding aldehyde with hydrogen cyanide in presence of aprotic solvent and catalyst | SHELL OIL COMPANY (US) | 1986-06-10 | — | — | US | disclosed |
| US-4582646-A | REACTING A NON-SYMMETRICAL KETENE WITH A RACEMIC OR OPTICALLY ACTIVE ALPHA-HYDROXYNITRILE | SHELL OIL COMPANY (US) | 1986-04-15 | — | — | US | disclosed |
| US-4570017-A | Preparation of optically-active (mixed) anhydrides and acids | SHELL OIL COMPANY (US) | 1986-02-11 | — | — | US | disclosed |
| US-4560515-A | NON-SYMMETRICAL KETENE REACTED WITH A-HYDROXYNITRILE; TERTUARY AMINE CATALYST | SHELL OIL COMPANY (US) | 1985-12-24 | — | — | US | disclosed |
| US-4529810-A | Preparation of optically-active alpha-substituted carboxylic esters and acids | SHELL OIL COMPANY (US) | 1985-07-16 | — | — | US | disclosed |
| EP-0116914-A1 | Preparation of optically-active alpha-substituted carboxylic esters and acids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-08-29 | — | — | EP | disclosed |
| EP-0109681-A2 | process for the preparation of optically-active cyanomethyl esters | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306165-A1 | DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE | FOLH1, SLC7A1, HNMT | CYP3A4 1600/4885SLC7A5 12/4885HRH4 132/4885 |
| US-20110301180-A1 | Reducing Platelet Activation, Aggregation and Platelet-Stimulated Thrombosis or Blood Coagulation by Reducing Mitochondrial Respiration | PC, PFKP, UQCRC1 | CYP3A4 338/4885SLC7A5 4466/4885HRH4 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.