Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1532534 | 1.00 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27541751 | 1.00 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7321531 | 1.00 | CYP3A4 (0.65) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL262239 | 0.98 | CYP3A4 (0.67) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL1581156 | 0.98 | CYP3A4 (0.67) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL3846866 | 0.98 | CYP3A4 (0.67) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Histidine SCHEMBL27489002 | 0.94 | CYP3A4 (0.76) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Histidine SCHEMBL27511747 | 0.94 | CYP3A4 (0.76) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28331180 | 0.88 | CYP3A4 (0.69) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 | |
| SCHEMBL388562 | 0.87 | CYP3A4 (0.73) | CYP3A4SLC7A5HRH4HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106674230-B | The synthetic method of pro-his cyclic dipeptide | 陕西慧康生物科技有限责任公司 | 2019-07-02 | — | — | CN | claimed |
| CN-108440653-A | A kind of synthetic method of Buserelin compound | 海南医学院 | 2018-08-24 | — | — | CN | claimed |
| CN-105534957-B | A kind of core-shell structure nanometer particle of reduction/enzyme/pH multiple responses drug release | 暨南大学 | 2018-05-08 | — | — | CN | claimed |
| CN-105085404-B | The pyrene compound of histidine methylester modification and its synthetic method and application | 华南师范大学 | 2017-08-08 | — | — | CN | claimed |
| CN-105085404-A | Pyrene compound modified with dl-histidine monohydrochloride and synthetizing method and application thereof | UNIV SOUTH CHINA NORMAL | 2015-11-25 | — | — | CN | claimed |
| CN-118184926-A | Amino acid functionalized chiral covalent organic framework material and preparation and application thereof | 周口师范学院 | 2024-06-14 | — | — | CN | disclosed |
| CN-112263708-B | Multifunctional aerogel dressing for promoting wound healing and preparation method thereof | 上海交通大学 | 2021-09-28 | — | — | CN | disclosed |
| CN-112263708-A | Multifunctional aerogel dressing for promoting wound healing and preparation method thereof | 上海交通大学 | 2021-01-26 | — | — | CN | disclosed |
| CN-105073757-B | Dyeing process using a hair-dyeing precursor obtained from an iridoid, composition, precursor and device comprising such a precursor | 莱雅公司 | 2019-12-17 | — | — | CN | disclosed |
| CN-110408584-A | Left-handed chirality nanogel cell scaffold material and preparation method thereof | UNIV SHANGHAI JIAOTONG | 2019-11-05 | — | — | CN | disclosed |
| CN-106674230-B | The synthetic method of pro-his cyclic dipeptide | 陕西慧康生物科技有限责任公司 | 2019-07-02 | — | — | CN | disclosed |
| CN-108640964-A | A kind of triterpene-amino acid derivativges, preparation method and application | 昆明理工大学 | 2018-10-12 | — | — | CN | disclosed |
| CN-105085404-B | The pyrene compound of histidine methylester modification and its synthetic method and application | 华南师范大学 | 2017-08-08 | — | — | CN | disclosed |
| CN-106632570-A | Peotopanaxadiol ginsenoside derivative and preparation method and application thereof | 李晓辉 | 2017-05-10 | — | — | CN | disclosed |
| CN-106573895-A | Novel 5-acylsulfanyl-histidine compounds as precursors for the corresponding 5-sulfanylhistidines and disulfides thereof | 特瑞海德公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-103936724-B | The fluorescent probe of test set propylhomoserin and presoma thereof and their preparation method | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-02-17 | — | — | CN | disclosed |
| CN-105085404-A | Pyrene compound modified with dl-histidine monohydrochloride and synthetizing method and application thereof | UNIV SOUTH CHINA NORMAL | 2015-11-25 | — | — | CN | disclosed |
| CN-104492395-A | Bionic immune adsorbent using PAMAM (polyamidoamine) as spacer arm as well as preparation method and application thereof | JAFRON BIOMEDICAL CO LTD | 2015-04-08 | — | — | CN | disclosed |
| CN-104277227-A | Siloxane polymer with a central polysiloxane polymer block with terminal organofunctional radicals comprising urea and/or carbamate groups and amino acid radicals | EVONIK INDUSTRIES AG | 2015-01-14 | — | — | CN | disclosed |
| CN-1098408-A | The heterocycle inhibitor of farnesyl-protein transferase | BRISTOL MYERS SQIBB COMPANY (US) | 1995-02-08 | — | — | CN | disclosed |