Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 13/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854464 | 0.89 | PTGER1 (0.42) | PTGER1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3847525 | 0.87 | PTGER1 (0.48) | PTGER1 | |
| SCHEMBL3856743 | 0.83 | PTGER1 (0.46) | PTGER1LMNATSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL4795243 | 0.82 | PTGER1 (0.70) | PTGER1 | |
| SCHEMBL3587201 | 0.79 | PTGER1 (0.50) | PTGER1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3578786 | 0.76 | PTGER1 (0.65) | PTGER1LMNACYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3583491 | 0.75 | PTGER1 (0.66) | PTGER1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3854465 | 0.75 | PTGER1 (0.46) | PTGER1 | |
| SCHEMBL3581181 | 0.71 | PTGER1 (0.48) | PTGER1 | |
| SCHEMBL3666730 | 0.70 | KDM1A (0.43) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102188-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008074833-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |