Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847829 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KDM4EPOLBHPGDHTT | |
| SCHEMBL17043093 | 0.89 | P2RX3 (0.48) | ALDH1A1KDM4EPOLBHPGDHTT | |
| SCHEMBL17043096 | 0.89 | P2RX3 (0.48) | ALDH1A1KDM4EPOLBHPGDHTT | |
| SCHEMBL1306703 | 0.81 | HDAC1 (0.49) | ALDH1A1KDM4EHPGDHTTLMNA | |
| SCHEMBL29488482 | 0.81 | HDAC1 (0.49) | ALDH1A1KDM4EHPGDHTTLMNA | |
| SCHEMBL1306701 | 0.81 | HDAC1 (0.49) | ALDH1A1KDM4EHPGDHTTLMNA | |
| SCHEMBL1306224 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBHPGDSMN1; SMN2 | |
| SCHEMBL1306225 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBHPGDSMN1; SMN2 | |
| SCHEMBL1305813 | 0.79 | ADAMTS4 (0.41) | ALDH1A1KDM4EHPGDLMNASMN1; SMN2 | |
| SCHEMBL29488485 | 0.78 | HPGD (0.45) | ALDH1A1KDM4EHPGDTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089354-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Korea Research Institute Of Chemical Technology (KR) | 2009-08-19 | — | — | EP | claimed |
| WO-2008054154-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-05-08 | — | — | WO | claimed |