Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670566 | 0.91 | NPC1 (0.65) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL29803616 | 0.91 | NPC1 (0.65) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL3846749 | 0.85 | NPC1 (0.59) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL30897434 | 0.82 | RAB9A (0.54) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL20898403 | 0.79 | LMNA (0.66) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL14695827 | 0.79 | NPC1 (0.55) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL31238369 | 0.78 | TAS1R3 (0.86) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL29800850 | 0.77 | NPC1 (0.55) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL23242595 | 0.77 | NPC1 (0.55) | RAB9AKMT2ALMNANPC1SMN1; SMN2 | |
| SCHEMBL3850184 | 0.77 | SORT1 (0.73) | RAB9AKMT2ALMNANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |