Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 2/20 | 0.47 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.47 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719657 | 0.77 | DGAT1 (0.54) | ALDH1A1SMN1; SMN2PKMLMNAGABRA1 | |
| Hydrochloric Acid SCHEMBL31426389 | 0.76 | DGAT1 (0.53) | ALDH1A1SMN1; SMN2PKMLMNAGABRA1 | |
| SCHEMBL3845583 | 0.75 | PKM (0.43) | SIK1SIK2SIK3ALDH1A1ATM | |
| SCHEMBL13666321 | 0.74 | FGFR1 (0.51) | ALDH1A1SMN1; SMN2MAPK1GAAATM | |
| SCHEMBL18584398 | 0.72 | FGFR1 (0.68) | SIK1SIK2SIK3ALDH1A1MAPK1 | |
| SCHEMBL31144757 | 0.71 | HCAR1 (0.48) | ALDH1A1MAPK1ATMHTTHPGD | |
| SCHEMBL15638670 | 0.71 | HCAR1 (0.48) | ALDH1A1MAPK1ATMHTTHPGD | |
| SCHEMBL15639073 | 0.71 | FGFR1 (0.50) | SIK1SIK2SIK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL24074850 | 0.71 | ESR2 (0.52) | HTTMEN1KMT2AHPGD | |
| SCHEMBL31621322 | 0.70 | DGAT1 (0.50) | ALDH1A1SMN1; SMN2GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |