Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 7/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | TACR2 | P21452 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849887 | 1.00 | PPARG (0.53) | PPARGPLA2G2AADAM17PPARACYP2C9 | |
| SCHEMBL3858100 | 0.90 | ADAM17 (0.56) | PPARGPLA2G2AADAM17CYP2C9CYP1A2 | |
| SCHEMBL3858097 | 0.90 | ADAM17 (0.56) | PPARGPLA2G2AADAM17CYP2C9CYP1A2 | |
| SCHEMBL3854171 | 0.86 | PLA2G2A (0.48) | PLA2G2AADAM17PLA2G1B | |
| SCHEMBL3854169 | 0.86 | PLA2G2A (0.48) | PLA2G2AADAM17PLA2G1B | |
| SCHEMBL2004289 | 0.83 | PLA2G2A (0.59) | PPARGPLA2G2APPARACYP2C9EGFR | |
| SCHEMBL3854426 | 0.83 | PLA2G2A (0.49) | PPARGPLA2G2AADAM17PLA2G1B | |
| SCHEMBL3854423 | 0.83 | PLA2G2A (0.49) | PPARGPLA2G2AADAM17PLA2G1B | |
| SCHEMBL3855493 | 0.82 | ADAM17 (0.54) | PPARGPLA2G2AADAM17CYP2C9CYP1A2 | |
| SCHEMBL3855489 | 0.82 | ADAM17 (0.54) | PPARGPLA2G2AADAM17CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576222-B2 | N-{[4-(but-2-ynyloxy)phenyl]sulfonyl}-1-(2-fluorobenzyl)-5-methoxy-2-methyltryptophan; for treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, ulcerative colitis, or Crohn's disease | WYETH (US) | 2009-08-18 | — | — | US | disclosed |
| US-20060160884-A1 | Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160884-A1 | Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase | ADAM17, TPSAB1, ADAM10 | PPARG 4511/4885PLA2G2A 3197/4885ADAM17 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.