Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 5/20 | 0.39 |
| ▸ | FABP3 | P05413 | 3/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846673 | 0.89 | FAAH (0.43) | CLK1DYRK1A | |
| SCHEMBL3851968 | 0.85 | FLT3 (0.40) | CLK1DYRK1AFLT3 | |
| SCHEMBL3847437 | 0.84 | L3MBTL1 (0.40) | CLK1DYRK1AFLT3 | |
| SCHEMBL13874137 | 0.83 | FLT3 (0.51) | CLK1DYRK1AFLT3 | |
| SCHEMBL3849735 | 0.82 | CLK1 (0.38) | CLK1DYRK1AFLT3 | |
| Hydrochloric Acid SCHEMBL3856691 | 0.82 | FLT3 (0.50) | CLK1DYRK1AFLT3 | |
| Hydrochloric Acid SCHEMBL3845911 | 0.81 | GABRA1 (0.41) | CLK1DYRK1AFLT3 | |
| Hydrochloric Acid SCHEMBL3854393 | 0.81 | FLT3 (0.42) | FLT3 | |
| SCHEMBL14145573 | 0.80 | LTB4R (0.38) | LTB4RFABP4FABP3CLK1DYRK1A | |
| SCHEMBL3847634 | 0.80 | FLT3 (0.46) | CLK1DYRK1AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |