Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazoline SCHEMBL760382 | 0.86 | EGFR (0.65) | ALDH1A1GLAHPGDEGFRKDM4E | |
| Quinoline SCHEMBL3706558 | 0.83 | ALDH1A1 (0.52) | ALDH1A1GLAHPGDMAPTEGFR | |
| Purine SCHEMBL3157 | 0.81 | — | — | |
| Purine SCHEMBL6421376 | 0.81 | KDM4A (0.38) | ALDH1A1GLAHPGDMAPTEGFR | |
| Purine SCHEMBL29456595 | 0.81 | — | — | |
| Purine SCHEMBL2120547 | 0.81 | KDM4A (0.38) | ALDH1A1GLAHPGDMAPTEGFR | |
| Benzimidazole SCHEMBL14678248 | 0.81 | KDM4E (0.40) | ALDH1A1GLAHPGDMAPTEGFR | |
| Isoquinoline SCHEMBL3607434 | 0.80 | EGFR (0.43) | ALDH1A1GLAHPGDEGFRKDM4E | |
| Purine SCHEMBL37119 | 0.79 | KDM4A (0.37) | ALDH1A1GLAHPGDMAPTEGFR | |
| Purine SCHEMBL1389668 | 0.79 | KDM4A (0.37) | ALDH1A1GLAHPGDMAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579373-B2 | Targeted bisplatinum polyamines as pro-drugs: selective release of platinum | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2009-08-25 | — | — | US | disclosed |
| EP-1427739-A4 | TARGETED BISPLATINUM POLYAMINES AS PRO-DRUGS: SELECTIVE RELEASE OF PLATINUM | UNIV VIRGINIA COMMONWEALTH (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1427739-A1 | TARGETED BISPLATINUM POLYAMINES AS PRO-DRUGS: SELECTIVE RELEASE OF PLATINUM | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2004-06-16 | — | — | EP | disclosed |
| US-20030114433-A1 | Targeted bisplatinum polyamines as pro-drugs: selective release of platinum | VIRGINIA COMMONWEALTH UNIVERSITY | 2003-06-19 | — | — | US | disclosed |
| WO-2003018594-A1 | TARGETED BISPLATINUM POLYAMINES AS PRO-DRUGS: SELECTIVE RELEASE OF PLATINUM | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114433-A1 | Targeted bisplatinum polyamines as pro-drugs: selective release of platinum | SRM, SMS, PARG | ALDH1A1 2930/4885GLA 4696/4885HPGD 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.