Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28441041 | 0.83 | TSHR (0.64) | ALDH1A1KMT2ATSHRSMN1; SMN2LMNA | |
| SCHEMBL13098104 | 0.82 | NPC1 (0.57) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24670566 | 0.79 | NPC1 (0.65) | ALDH1A1KMT2ARAB9ATSHRNPC1 | |
| SCHEMBL29803616 | 0.79 | NPC1 (0.65) | ALDH1A1KMT2ARAB9ATSHRNPC1 | |
| SCHEMBL3846113 | 0.79 | GPR27 (0.53) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27181169 | 0.79 | GPR27 (0.56) | ALDH1A1KMT2ARAB9ATSHRNPC1 | |
| SCHEMBL3849125 | 0.79 | RAB9A (0.56) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3846350 | 0.78 | SMN1; SMN2 (0.64) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28349237 | 0.77 | TP53 (0.68) | ALDH1A1KMT2ARAB9ATSHRNPC1 | |
| SCHEMBL3846752 | 0.76 | SMN1; SMN2 (0.56) | ALDH1A1KMT2ARAB9ATSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |