Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301405 | 0.80 | KMT2A (0.56) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL3850292 | 0.79 | GPR27 (0.61) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL29556014 | 0.76 | MEN1 (0.74) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL3852009 | 0.76 | ALDH1A1 (0.52) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL24670924 | 0.75 | RAB9A (0.69) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL3851218 | 0.75 | RAB9A (0.78) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL27181188 | 0.74 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AKMT2ANPC1LMNA | |
| SCHEMBL30926970 | 0.74 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AKMT2ANPC1LMNA | |
| SCHEMBL4878207 | 0.74 | CYP11B2 (0.72) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL2693414 | 0.74 | MAPT (0.57) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |