Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 12/20 | 0.51 |
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845645 | 0.84 | SORT1 (0.73) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3851843 | 0.83 | NPC1 (0.57) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3850184 | 0.81 | SORT1 (0.73) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3845400 | 0.81 | NPC1 (0.51) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL20332736 | 0.76 | SORT1 (0.71) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL3846118 | 0.73 | SORT1 (0.73) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL11466907 | 0.72 | DEGS1 (0.56) | RAB9ANPC1SMN1; SMN2KMT2AGAA | |
| SCHEMBL3849262 | 0.72 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6949627 | 0.72 | DEGS1 (0.48) | SORT1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL31508206 | 0.71 | SMN1; SMN2 (0.43) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |